Z-VAD-FMK, General Caspase Inhibitor

Product Information

Material Number: 550377

Size: 1.0 mg

Storage Buffer: Lyophilized in dimethyl sulfoxide (DMSO).

Description

Members of the caspase family play key roles in inflammation and mammalian apoptosis. Z-VAD-FMK is a cell permeable general caspase 

inhibitor that irreversibly binds to the catalytic site of caspase proteases and inhibits apoptosis. The peptide is O-methylated in the P1 position 

on aspartic acid providing enhanced stability and increased cell permeability. Z-VAD-FMK has a molecular weight of 467 Daltons.

Preparation and Storage

Avoid multiple freeze-thaws of product.

Store the lyophilized Z-VAD-FMK inhibitor at -20?C. Reconstitute the Z-VAD-FMK inhibitor in DMSO before use. The reconstituted Z-VAD-FMK inhibitor may be stored in small aliquots at -20?C.

Application Notes

Application

Flow cytometry               Routinely Tested

Suggested Companion Products

Catalog Number  Name                                                            Size         Clone

559763             PE Annexin V Apoptosis Detection Kit I              100 tests  (none)

550411             Z-FA-FMK, Negative Control for Caspase Inhibitors 1.0 mg     (none)

Product Notices

 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.