Z-IETD-FMK, Caspase-8 Inhibitor

Product Information

Material Number: 550380

Size: 1.0 mg

Storage Buffer: Lyophilized in dimethyl sulfoxide (DMSO).

Description

Members of the caspase family play key roles in inflammation and mammalian apoptosis. Z-IETD-FMK is an irreversible and cell permeable inhibitor of caspase-8. The peptide is O-methylated in the P1 position on aspartic acid providing enhanced stability and increased cell permeability. This inhibitor can be used to inhibit caspase-8 activity and to study events downstream of caspase-8 activation. Z-IETD-FMK has a molecular weight of 654 Daltons.

Preparation and Storage

Avoid multiple freeze-thaws of product.

Store the lyophilized Z-IETD-FMK inhibitor at -20°C. Reconstitute the Z-IETD-FMK inhibitor in DMSO before use. The reconstituted Z-IETD-FMK inhibitor may be stored in small aliquots at -20°C.

Application Notes

Application

Fluorescence quantitation            Routinely Tested

Suggested Companion Products

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559763             PE Annexin V Apoptosis Detection Kit I 100 tests (none)

Product Notices

 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results