非肌肉肌球蛋白II型ATP酶抑制剂，Blebbistatin 是一种选择性的非肌肉肌球蛋白 II (NMII) 抑制剂，可促进角膜内皮细胞的定向迁移并加速伤口愈合，并更好地保留细胞连接完整性和屏障功能。
中文名称
(±)-Blebbistatin
中文别名
(卤)-Blebbistatin
英文名称
(±)-Blebbistatin
英文别名
(+/-)-Blebbistatin;(±)-Blebbistatin;(±)-Blebbistatin ((R;3a-hydroxy-6-methyl-1-phenyl-2,3-dihydropyrrolo[2,3-b]quinolin-4-one;Blebbistatin;( inverted exclamation markA)-Blebbistatin;1-Phenyl-1,2,3,4-tetrahydro-4-hydroxypyrrolo(2.3-b)-7-methylquinolin-4-one;(+/-)-1,2,3,3a-Tetrahydro-3a-hydroxy-6-methyl-1-phenyl-4H-pyrrolo[2,3-b]quinolin-4-one;3a-hydroxy-6-methyl-1-phenyl-3,3a-dihydro-1H-pyrrolo[2,3-b]quinolin-4(2H)-one;(+-)-Blebbistatin;Blebbistain;Bleb;Probes1_000318;Probes1_00032
Cas No.
674289-55-5
分子式
C18H16N2O2
分子量
292.33
生物活性
Blebbistatin is a selective non-muscle myosin II (NMII) inhibitor, promotes directional migration of corneal endothelial cells (CECs) and accelerates wound healing, and better preserves cell junctional integrity and barrier function. Blebbistatin blocks cell migration.
性状
Solid
IC50 & Target[1][2]
Non-muscle myosin II (NMII)
体外研究(In Vitro)
The therapeutic potential of targeting NMII to enhance CEC migration is investigated using bovine corneal endothelial cells (BCECs). Blebbistatin, a direct myosin motor inhibitor, promotes migration and directional persistence in CECs through decreasing actin retrograde flow and increasing lamellipodial protrusion persistence to accelerate wound healing 体外研究.
Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)
Blebbistatin (0.05 mL, 20 μM; intracameral injection; daily; for 6 days; New Zealand white rabbits) treatment promotes wound healing in rabbit corneal endothelial scraping model.
Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Model: New Zealand white rabbits (16-20 weeks; 3-3.5 kg)
Dosage: 0.05 mL; 20 μM
Administration: Intracameral injection; daily; for 6 days
Result: Resulted in significant improvement of corneal clarity and corneal edema resolution, implying the restoration of an intact corneal endothelial monolayer.
运输条件
Room temperature or refrigerated transportation.
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Medlife小分子化合物大量库存，提供超过2万种的抑制剂、激动剂、拮抗剂等产品，是药物及疾病研究的重要原料供应商。
