简介：Dorsomorphin 是一种有效的 ATP 竞争性的选择性 AMPK 抑制剂,Ki 为 109±16 nM。
物理化学性质：
密度 1.3±0.1 g/cm3
分子式 C24H25N5O
分子量 399.488
精确质量 399.205902
PSA 55.55000
LogP 2.39
外观性状 固体;White to Yellow to Orange powder to crystal
折射率 1.670
储存条件 0-10°C;存放于惰性气体之中;避免空气,加热
详细介绍：
产品名称： [Perfemiker]Dorsomorphin,≥98%
中文别名： 6-[4-(2-哌啶-1-基乙氧基)苯基]-3-吡啶-4-基吡唑并[1,5-A]嘧啶;6-[4-[2-(1-哌啶基)乙氧基]苯基]-3-(4-吡啶基)吡唑并[1,5-A]嘧啶;BML-275 抑制剂;Dorsomorphin(化合物C)
英文名称： Dorsomorphin
英文别名： 6-(4-(2-(Piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine;Dorsomorphin;6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine;BML-275;Dorsomorphin (Compound C, BML-275);Dorsomorphin dihydrochloride;Pyrazolo[1,5-a]pyrimidine,6-[4-[2-(1-piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)-;AMPK Inhibitor,Compound C;BML275;Compound C;AMPK Inhibitor;AMPK Inhibitor, Compound C;Dorsomorphin (Compound C);4-(6-{4-[2-(piperidin-1-yl)ethoxy]phenyl}pyrazolo[1,5-a]pyrimidin-3-yl)pyridine;6-{4-[2-(piperidin-1-yl)ethoxy]phenyl}-3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine;Dorsomo
品牌： Perfemiker
CAS号： 866405-64-3
分子式： C24H25N5O
分子量： 399.49
纯度： ≥98%
详细描述： 创赛优选商城提供的Dorsomorphin,≥98%为创赛科技出品的其它合成试剂,产品稳定,定制速度快,极大地方便了广大科研客户的使用需求。产品包装为100mg。查询关键词:其它合成试剂，866405-64-3，Dorsomorphin,≥98%，Dorsomorphin，博飞美科，Perfemiker，上海，厂家现货。
参考文献：
[1]. Zhou G, et al. Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest. 2001 Oct;108(8):1167-74.
[2]. Saito S, et al. Compound C prevents the unfolded protein response during glucose deprivation through a mechanism independent of AMPK and BMP signaling. PLoS One. 2012;7(9):e45845.
[3]. Yu PB, et al. Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism. Nat Chem Biol. 2008 Jan;4(1):33-41.
[4]. Chen L, et al. Activating AMPK to Restore Tight Junction Assembly in Intestinal Epithelium and to Attenuate Experimental Colitis by Metformin. Front Pharmacol. 2018 Jul 16;9:761.
